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Indianapolis Colts quarterback Andrew Luck carries the ball in the first half against the San Francisco 49ers Sunday in San Francisco. Associated Press.

NFL Review: Panthers hammer Giants; Luck leads Colts

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CHARLOTTE, N.C. (AP) — Cam Newton threw three touchdown passes and ran for another, and Carolina sacked Eli Manning seven times as the Panthers handed Tom Coughlin his worst defeat as coach of the New York Giants, 38-0 Sunday.

It was the largest margin of victory in Panthers history.

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