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In this May 7, 2010 file photo, talk-show host Oprah Winfrey is seen with interior designer Nate Berkus, left, Dr. Mehmet Oz and Dr. Phil McGraw, right, during "The Oprah Winfrey Show" live from Radio City Music Hall in New York. "The Oprah Winfrey Show" is ending its run in Chicago on May 25, 2011, after 25 years, and millions of her fans around the globe are waiting to see how she will close out a show that spawned a media empire. The three are Winfrey's proteges, who she fostered to their own televisi...

Questions linger about end of 'Oprah Winfrey' show

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CHICAGO (AP) -- Oprah Winfrey has given the world 25 years of poets and politicians, A-list actors and musicians and talk show topics that defined and reflected American culture.

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As "The Oprah Winfrey Show" ends, with 16 episodes left as of May 4, her millions of fans around the globe are waiting to see how she will close out a show that engineered a media empire.

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